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HYDROXYMETHOXYBENZYL PELARGONAMIDE

CAS 2444-46-4
30

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Hydroxymethoxybenzyl Pelargonamide is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Hydroxy-methoxy-benzyl Pelargonamide is chemically identical to Nonivamide (pelargonoyl vanillinamide, CAS 2444-46-4), a synthetic capsaicin analog used as a fragrance compound and warming agent. The GHS classification is severe: H301 (toxic if swallowed), H315 (skin irritant), H317 (skin sensitizer), H318 (serious eye damage), H319 (eye irritant), H334 (respiratory sensitizer), H335 (respiratory irritant), with Danger as signal word. In the EU, it may appear in Annex III under fragrance allergen provisions. Its extreme irritancy at low concentrations makes it suitable only for specialized professional formulations.

Skin benefits

  • Provides warming sensation as capsaicin analog in specialized formulations
  • Used in limited therapeutic/cooling formulations at controlled doses

Known concerns

  • H301 — Acute toxicity if swallowed
  • H317 — Skin sensitizer (potential for allergic contact dermatitis)
  • H318 — Serious eye damage potential
  • H334 — Respiratory sensitizer
  • H335 — Respiratory irritant
  • Classified as Dangerous (GHS) — requires professional handling

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.