Prohibited substance
1,1-Bis(dimethylaminomethyl)propyl benzoate (amydricaine, alypine) and its salts
Safety score · 0–100
Avoid
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
Amydricaine (alypine), a historical local anaesthetic now prohibited in EU cosmetics. As a pharmacologically active drug it has no place in personal care products and is banned outright.
Skin benefits
- Historical use as a local anaesthetic in medicine
- No legitimate cosmetic benefit
Known concerns
- Listed on EU Annex II of substances prohibited in cosmetic products
- Active pharmaceutical agent (local anaesthetic) inappropriate for cosmetics
- Cardiotoxic and CNS-toxic at systemic exposure
- Risk of masking pain or injury when applied to skin
- Salts of amydricaine are equally prohibited
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related prohibited substances
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.