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Lobeline (INN) and its salts

CAS 90-69-7
15

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Lobeline (inn) And Its Salts is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Lobeline is a piperidine alkaloid with pharmacological activity on nicotinic acetylcholine receptors, producing emetic, respiratory stimulant, and hypertensive effects. GHS classification includes H301+H311+H331 (Toxic if swallowed, in contact with skin or if inhaled). The EU Cosmetics Regulation Annex II prohibits substances with significant systemic toxicity in cosmetics; lobeline's acute toxicity profile precludes any safe cosmetic application.

Known concerns

  • EU Annex II restricted — acute systemic toxicity H301+H311+H331
  • CNS and respiratory effects
  • Emetic properties — not suitable for oral/dermal cosmetics

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.