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Methapyrilene (INN) and its salts

CAS 91-80-5
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Methapyrilene (INN) and its salts is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Methapyrilene (CAS 91-80-5) is an antihistamine agent historically used in cosmetic formulations but now banned. Under EU Regulation (EC) 1223/2009, it is listed in Annex II (banned substances) as it has been classified as a Category 3 carcinogen (suspected of causing cancer) and is considered unsafe for cosmetic use. The ingredient has been removed from the CosIng database for cosmetic use and is included in the SCCS notes on suspected carcinogens.

Known concerns

  • EU Annex II banned substance
  • Suspected carcinogen (Category 3)
  • CMR substance

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.