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Metheptazine (INN) and its salts

CAS 469-78-3
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Metheptazine (inn) And Its Salts is a cosmetic ingredient. Exercise caution due to limited available safety data.

Metheptazine is an opioid-type analgesic compound. Like other pharmacologically active substances with significant systemic effects, it is prohibited in EU Annex II from use in cosmetic products at concentrations >=0.1%. The EU cosmetic regulation takes a precautionary stance on substances with known pharmacological activity that could pose risks through dermal absorption in cosmetic formulations.

Known concerns

  • EU Annex II banned at >=0.1%
  • Potent pharmacological activity (opioid class)
  • Systemic absorption risk via skin

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.