Other
Phenylpropanolamine hydrochloride [USAN:INN:BAN]
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
Phenylpropanolamine Hydrochloride [usan:inn:ban] is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.
Phenylpropanolamine Hydrochloride (CAS 154-41-6) is a synthetic sympathomimetic amine with amphetamine-like pharmacological activity, historically used as a decongestant and weight-loss agent in pharmaceuticals. It carries H302 (harmful if swallowed). The EU Cosmetic Regulation Annex II would exclude this substance from cosmetic use given its pharmaceutical drug status and potential systemic cardiovascular effects. Its presence in a cosmetic ingredient database is likely archival; it has no established safe use level in topical cosmetic formulations under EU regulatory frameworks. This compound should not be used in cosmetic products per EU drug/cosmetic boundary interpretations.
Known concerns
- Pharmaceutical drug substance with sympathomimetic activity
- H302 - harmful if swallowed
- Cardiovascular effects (vasoconstriction) preclude topical cosmetic use
- Not permitted in EU cosmetics - regulatory exclusion based on drug status
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related others
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.