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norfenefrine

CAS 536-21-0
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Norfenefrine is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Norfenefrine is a phenethylamine derivative with sympathomimetic (alpha-adrenergic) activity, functioning as a vasoconstrictor similar to phenylephrine. It has been used in topical pharmaceutical preparations for nasal decongestion and circulatory support. The compound's pharmacological activity raises concerns for cosmetic skin care use, particularly around systemic absorption through damaged or compromised skin barriers, cardiovascular effects (including blood pressure changes), and potential interactions with cardiovascular medications. Limited data exist on its long-term topical safety profile in cosmetic applications. It is not listed as a permitted cosmetic ingredient in EU Annexes, suggesting it is regarded as a pharmaceutical rather than cosmetic substance.

Skin benefits

  • Vasoconstrictor in topical pharmaceutical formulations — may reduce puffiness

Known concerns

  • Cardiovascular activity — vasoconstrictive effects
  • Systemic absorption concerns
  • Limited cosmetic safety data
  • Pharmaceutical rather than cosmetic profile

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.