N'1-quinoxalin-2-ylsulphanilamide, sodium salt
Other
Avoid
CAS Number: 967-80-6
About N'1-quinoxalin-2-ylsulphanilamide, sodium salt
A sulfonamide antimicrobial drug derivative that is effectively prohibited from cosmetic use in the EU, with regulations mandating it not be placed on the market above 0.1% or used as an aerosol propellant.
Detailed Analysis
N'1-quinoxalin-2-ylsulphanilamide sodium salt (CAS 967-80-6) is a quinoxaline sulfonamide compound closely related to veterinary sulfonamide antibiotics. EU CosIng data reveal extensive restriction language, including: prohibition above 0.1% by weight as a substance or in mixtures, a specific ban on aerosol propellant use, and the requirement that it shall not be placed on the market in concentrations equal to or greater than 0.1%. This places the ingredient in the most restricted category under EU cosmetic regulation — equivalent to Annex II banned substance treatment despite technically appearing in Annex III due to the severity and breadth of restrictions. Sulfonamides raise concerns about antimicrobial resistance and potential cross-sensitivity with sulfonamide drug reactions.
Known Concerns
- ⚠ EU Annex III severely restricted — prohibited above 0.1% in any form
- ⚠ Banned as aerosol propellant (EU regulation)
- ⚠ Shall not be placed on the market above 0.1% — effectively near-annex II status
- ⚠ Sulfonamide antimicrobial — raises antimicrobial resistance concerns
- ⚠ Cross-sensitivity risk with sulfonamide drug allergies
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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