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N-(Trichloromethylthio)phthalimide (Folpet - ISO)

CAS 133-07-3
18

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

N-(Trichloromethylthio)phthalimide (Folpet - ISO) is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

Folpet (ISO) is a phthalimide-derived fungicide used in agriculture since the 1950s. Its hazard profile encompasses multiple serious concerns: H317 indicates skin sensitisation potential, H351 classifies it as a suspected carcinogen, H361 indicates reproductive toxicity, H372 indicates specific target organ toxicity with repeated exposure, and H330 indicates acute inhalation toxicity. Its trichloromethylthio group can dissociate to yield phthalimide and carbon disulfide. The compound is authorised as a pesticide but has no place in cosmetic formulations; the EU CosIng database does not list it as an authorised cosmetic ingredient.

Known concerns

  • H317: May cause allergic skin reaction
  • H319: Causes serious eye irritation
  • H330: Fatal if inhaled
  • H332: Harmful if inhaled
  • H351: Suspected of causing cancer
  • H361: Suspected of damaging the unborn child
  • H372: Causes damage to organs through prolonged or repeated exposure
  • H400/H410: Very toxic to aquatic life / with long-lasting effects
  • No EU cosmetic authorisation — agricultural fungicide

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

Related others

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.