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Skin Conditioning

NONAPEPTIDE-22

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic 9-amino-acid peptide used as a skin-conditioning active. Plausibly safe at trace levels; data is limited.

Nonapeptide-22 is a synthetic 9-residue peptide supplied as a cosmetic skin-conditioning active at parts-per-million levels. Numbered INCI nonapeptides are typically marketed for signaling-type benefits (firmness, brightening, visible-aging support) by specialty ingredient houses. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short-to-medium peptides have negligible intact skin penetration and very low irritation potential at use levels. Independent efficacy and long-term safety data are thin; real-world risk is dominated by the surrounding formulation.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Marketed signaling support
  • Low irritation potential

Known concerns

  • No regulatory monograph
  • Sparse independent data
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.