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NONOXYNOL-13

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)
32

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Restricted in EU cosmetic formulations, this higher ethoxylated surfactant can still release endocrine-disrupting nonylphenol and poses unresolved environmental risks.

Nonoxynol-13 is a nonionic surfactant of the ethoxylated nonylphenyl ether family with an average of 13 ethylene oxide units. EU cosmetic regulation (REACH Annex XVII) restricts its use regardless of ethoxylation degree, as the nonylphenyl component is the primary concern. Higher-ethoxylated Nonoxynols have somewhat reduced aquatic toxicity compared to lower homologues, but regulatory restrictions apply uniformly across the series.

Known concerns

  • EU REACH Annex XVII restriction in cosmetic products
  • Endocrine disruption via alkylphenyl degradation
  • Aquatic toxicity
  • Environmental persistence

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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BASIC VIOLET 1
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.