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NONOXYNOL-23

CAS 68412-54-4/ 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)
46

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

This higher ethoxylated Nonoxynol has a substantially lower endocrine disruption profile than lower variants, yet remains restricted in EU cosmetic formulations under REACH Annex XVII.

Nonoxynol-23 is a polyethylene glycol mono(4-nonylphenyl) ether with an average of 23 ethylene oxide units. At this ethoxylation level, the surfactant's propensity to degrade to free nonylphenol is significantly reduced, and its aquatic toxicity is moderate to low. Nonetheless, EU REACH Annex XVII entry 46a imposes a class-wide restriction on nonylphenol ethoxylates in cosmetic products, encompassing Nonoxynol-23. Environmental persistence in water bodies remains a concern at trace concentrations.

Known concerns

  • EU REACH Annex XVII restriction in cosmetic products
  • Residual endocrine disruption risk
  • Aquatic toxicity at environmental concentrations
  • Persistence in sewage effluent

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.