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NONOXYNOL-3

CAS 9016-45-9 (generic)/ 26027-38-3 (generic)/ 37205-87-1 (generic)/ 84562-92-5 (generic)/ 51437-95-7 (generic)/ 27176-95-0 (generic)
36

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

An ethoxylated alkyl phenol surfactant with concerns about potential endocrine disruption and environmental persistence, as well as 1,4-dioxane contamination risk from ethoxylation.

Nonoxynol-3 is a member of the Nonoxynol series of ethoxylated alkylphenols where the average degree of ethoxylation is 3. While higher nonoxynols (NP and OP) face specific EU restrictions due to endocrine-disrupting properties of their degradation products (4-nonylphenol, 4-tert-octylphenol), the low ethoxylation number means Nonoxynol-3 may contain more residual alkylphenol impurities. The ingredient is not formally restricted in EU Annexes, but the SCCS has expressed concern regarding alkylphenol residues in cosmetic formulations.

Skin benefits

  • Functions as a nonionic surfactant and emulsifier in formulations
  • Can act as a solubilising agent for hydrophobic ingredients

Known concerns

  • Potential alkylphenol (4-NP/4-tOP) contamination with endocrine-disrupting properties
  • Risk of 1,4-dioxane contamination from ethoxylation process
  • Environmental persistence of alkylphenol degradation products
  • Limited specific toxicological data for Nonoxynol-3 versus higher ethoxylates

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.