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Antioxidant

NORDIHYDROGUAIARETIC ACID

CAS 500-38-9 Updated
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A potent polyphenol antioxidant from creosote bush (NDGA). Pulled as a food additive in 1968 over liver and kidney toxicity, and tied to allergic contact reactions — real concerns for cosmetic use.

Function

ANTIOXIDANT

Skin benefits

  • Strong polyphenol antioxidant
  • Stabilizes oil-phase formulations against oxidation
  • Inhibits 5-lipoxygenase pathway

Known concerns

  • Hepatotoxicity and nephrotoxicity in oral case reports
  • Withdrawn as food antioxidant by FDA in 1968
  • Banned/restricted in many supplements; cosmetic use should be very low %
  • Allergic contact dermatitis reports

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.