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o-Dianisidine based azo dyes

8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

O-Dianisidine based azo dyes is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

o-Dianisidine (3,3'-dimethoxybenzidine) is classified as a confirmed human carcinogen by IARC (Group 1) and is listed in EU Annex II of Regulation 1223/2009 (prohibited substances). Azo dyes derived from o-dianisidine can be metabolically cleaved to release the parent carcinogenic amine, making the entire class unsuitable for cosmetic applications. EU regulations explicitly prohibit these colorants in all cosmetic product types.

Known concerns

  • IARC Group 1 confirmed carcinogen (o-dianisidine)
  • EU Annex II banned substance
  • Metabolic cleavage to carcinogenic aromatic amine
  • Complete cosmetic prohibition

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.