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Skin Conditioning

OLIGOPEPTIDE-221 OLIGOPEPTIDE-133

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A combined INCI of two designer oligopeptides (oligopeptide-221 with oligopeptide-133) used for skin conditioning. Limited independent safety data.

This is a combination INCI representing a supplier blend of oligopeptide-221 and oligopeptide-133, both multi-residue synthetic peptides formulated for skin-conditioning cosmetic use. Such combination INCIs are typical of proprietary designer peptide actives sold as ready-to-use solutions. Use levels are at parts-per-million in serums and creams. Neither component has an independent CIR or SCCS review; combination performance relies on supplier studies. Conservative tier: yellow with low evidence; combining two unknowns warrants extra caution.

Function

SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Designer peptide blend for skin conditioning
  • Trace use levels
  • Compatible with most leave-on formulas

Known concerns

  • Two proprietary peptides combined — sparse safety data
  • No CIR/SCCS review
  • Performance entirely supplier-driven

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.