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P-METHOXYCINNAMALDEHYDE

CAS 1963-36-6
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

P-Methoxycinnamaldehyde is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

p-Methoxycinnamaldehyde is an aromatic aldehyde with a methoxy substituent on the benzene ring and an alpha,beta-unsaturated carbonyl system responsible for its distinctive spicy-sweet fragrance. The cinnamaldehyde scaffold is known to cause skin sensitization in susceptible individuals, though the methoxy substitution may moderate this effect. EU Regulation 1223/2009 requires allergen labeling for this compound when present above 0.001% in leave-on products. The compound demonstrates some antioxidant activity but is primarily valued for its fragrance contribution. The alpha,beta-unsaturated nature raises theoretical concerns about Michael addition reactivity with skin proteins, contributing to its sensitizing potential.

Skin benefits

  • Fragrance ingredient with pleasant aromatic profile
  • May provide mild antioxidant activity

Known concerns

  • Skin sensitization potential (alpha,beta-unsaturated aldehyde)
  • EU allergen labeling required above threshold
  • Potential for protein reactivity via Michael addition
  • May cause irritation in sensitive individuals

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.