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Skin Conditioning

PALMITOYL HEXAPEPTIDE-14

CAS -
65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A 6-amino-acid peptide capped with a palmitoyl fatty-acid tail for improved skin compatibility. Used at trace levels for skin conditioning; data is limited.

Palmitoyl Hexapeptide-14 is a synthetic hexapeptide acylated at the N-terminus with palmitic acid (C16). The lipid tail improves stability and partitioning into the lipid-rich upper stratum corneum, a strategy widely used for cosmetic peptides. It is supplied at parts-per-million levels for skin-conditioning and signaling-type benefits. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. As with related lipopeptides, irritation potential at use levels is low, but independent efficacy data is sparse. Practical risks are formulation-dependent.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Improved skin partitioning via lipidation
  • Low irritation potential

Known concerns

  • No regulatory review
  • Sparse independent data
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.