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Skin Conditioning

PALMITOYL SH-PENTAPEPTIDE-4

89

Safety score · 0–100

Good

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A palmitic-acid-anchored signal peptide (Matrixyl-class) that prompts skin to synthesise more collagen. Used at trace levels with one of the strongest safety records among cosmetic peptides.

Function

ANTIOXIDANTSKIN CONDITIONING

Skin benefits

  • Stimulates collagen and ECM synthesis
  • Well-studied anti-wrinkle peptide
  • Very low irritation
  • Effective at parts-per-million levels

Known concerns

  • Marketing claims often exceed evidence
  • Possible synthesis residuals

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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ALLANTOIN GLYCYRRHETINIC ACID
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ALOE BARBADENSIS LEAF JUICE POWDER
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ALTHAEA OFFICINALIS HAIRY ROOT EXTRACT
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AMINOBUTYRIC ACID
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ASPARAGINE
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Same plant / compound family

68
PALMITOYL SH-PENTAPEPTIDE-17 SP LYSINE AMIDOPROPYL DIGLYCOLPROPYLAMINE
Peptide / signal peptide complex
 85
PALMITOYL SH-PENTAPEPTIDE-21 SP AMIDE
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PALMITOYL SH-PENTAPEPTIDE-4 SP AMIDE
Skin Conditioning

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.