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Skin Conditioning

PENTAPEPTIDE-45

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic 5-amino-acid peptide for skin conditioning. Plausibly safe at trace levels; independent data is limited.

Pentapeptide-45 is a synthetic pentapeptide supplied for cosmetic use at parts-per-million levels as a skin-conditioning and signaling active. Like other numbered INCI pentapeptides, it is offered by individual ingredient houses for visible-aging or firmness benefits. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short peptides at trace levels have negligible intact skin penetration and very low irritation potential. Independent efficacy and long-term safety data are sparse; real-world risk is dominated by the surrounding formulation.

Function

SKIN PROTECTING

Skin benefits

  • Skin conditioning
  • Marketed signaling support
  • Low irritation potential

Known concerns

  • No regulatory monograph
  • Sparse independent data
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.