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Skin Conditioning

PICHIA SR-(POLYPEPTIDE-168 OLIGOPEPTIDE-178) FERMENT

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A Pichia yeast ferment engineered to produce specific peptides (polypeptide-168, oligopeptide-178). Marketed as anti-aging — safety looks fine but public data is thin.

This ingredient is a ferment broth from the yeast Pichia that has been engineered (or selected) to express two defined peptides, polypeptide-168 and oligopeptide-178. The finished ingredient delivers these bioactive peptides in a yeast-derived matrix. No formal CIR or SCCS reviews exist. Short peptides are generally low irritancy and not dermally absorbed in significant amounts; the main concerns are proprietary impurities, residual nutrient medium and the possibility of yeast-metabolite allergenicity. Typical use is at low percentages in leave-on serums.

Function

FILM FORMING, SKIN PROTECTING, VISCOSITY CONTROLLING

Skin benefits

  • Delivers yeast-derived peptides to skin
  • Skin conditioning and barrier support
  • Marketed for anti-aging applications

Known concerns

  • Proprietary biotech blend — limited independent data
  • Possible residual fermentation metabolites
  • Yeast-sensitive users may react

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.