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POLYGONUM MULTIFLORUM ROOT VESICLES

52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Fo-ti root vesicles, a classic herbal extract from traditional Chinese medicine, included in skincare for its rejuvenating and antioxidant properties.

Polygonum multiflorum (Fallopia multiflora) has been linked to multiple cases of idiosyncratic liver injury globally, including acute liver failure reports. The EU EMA has flagged quality control concerns for Polygonum multiflorum-containing products, and Chinese regulatory authorities have required warning labels. The root contains stilbene glucosides (piceid, polydatin) and anthraquinones. While the vesicles format may modulate the delivery of the active compounds, the underlying hepatotoxicity concern cannot be disregarded. Use in leave-on cosmetics warrants caution and low inclusion levels.

Skin benefits

  • Stilbene glucosides provide antioxidant and potential anti-aging benefits
  • Traditional use for hair health and skin darkening

Known concerns

  • Documented hepatotoxicity and idiosyncratic liver injury; EMA and Chinese NMPA warnings issued
  • Anthraquinone derivatives contribute to potential liver toxicity risk
  • Regulatory scrutiny; advisable to use at minimal concentrations in leave-on products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.