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POLYQUATERNIUM-1

CAS 75345-27-6 / 68518-54-7
72

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Polyquaternium-1 is a cosmetic ingredient used in product formulations. Note: classified as harmful to aquatic environments. Exercise caution due to limited available safety data.

Polyquaternium-1 (also known as Polyquad) is a quaternary ammonium polymer historically used as both a conditioning agent and a preservative in ophthalmic solutions. While it is not classified as a preservative under EU Regulation (EC) No 1223/2009, the SCCS has noted concerns regarding potential mutagenicity findings in early in vitro studies that are no longer considered relevant at actual use concentrations. It is not listed in EU Annex II (banned) or Annex III (restricted). Current scientific consensus supports its safety in cosmetic formulations at concentrations up to 0.1%, though it remains more common in the US market than in Europe.

Skin benefits

  • Excellent film-forming and conditioning properties on skin and hair
  • Provides antimicrobial preservation support in certain formulation types

Known concerns

  • Historical in vitro genotoxicity studies created regulatory scrutiny — considered outdated at current use levels
  • Not approved as a preservative in the EU; must be declared as an INC ingredient if present above 1%

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.