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PROGESTERONE

CAS 57-83-0
12

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A naturally occurring steroid hormone with significant regulatory restrictions in cosmetic products throughout the EU.

Progesterone is a steroid hormone listed in EU Regulation 1223/2009 Annex II (list of substances prohibited in cosmetic products) under reference II/194, indicating it is banned from cosmetic use in Europe. This restriction stems from its endocrine-disrupting potential and classification as a CMR (Carcinogenic, Mutagenic, or toxic to Reproduction) substance of category 2. Any cosmetic product containing progesterone would be non-compliant with EU law.

Known concerns

  • EU Annex II banned substance — prohibited in all cosmetic products
  • Endocrine-disrupting activity
  • CMR Category 2 classification
  • Systemic hormonal effects with topical absorption

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.