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Active Ingredient

SANGUINARIA CANADENSIS RHIZOME/ROOT EXTRACT

CAS 84929-48-6 Updated
20

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Bloodroot extract — contains sanguinarine, a cytotoxic alkaloid linked to oral leukoplakia when used in toothpastes. Restricted in many markets and inappropriate for most modern cosmetic use.

Function

CLEANSINGREFRESHINGSKIN CONDITIONINGTONIC

Skin benefits

  • Historical antimicrobial use in oral products

Known concerns

  • Sanguinarine is cytotoxic and pro-apoptotic
  • Linked to oral leukoplakia in toothpaste use
  • Severe skin/mucosal irritation
  • Banned/restricted in many cosmetic categories

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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Bitolterol mesylate [USAN]
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HUMAN EMBRYONIC KIDNEY CELL EXTRACELLULAR VESICLES
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SULINDAC
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Sodium Fluorosilicate
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.