Humectant
SILKWORM SH-POLYPEPTIDE-69
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A large 1466-amino-acid recombinant Collagen Alpha-1 (III) Chain produced in silkworm through transgenic technology, designed to support skin elasticity and structure.
Silkworm sh-Polypeptide-69 is a recombinant human Collagen Alpha-1 (III) Chain (up to 1466 amino acids) produced in transgenic silkworm (Bombyx mori). Collagen produced via transgenic expression in silkworms represents an innovative cosmetic ingredient. While recombinant collagens are not subject to EU cosmetic bans, the very large size and triple-helix-forming potential of type III collagen raises questions about skin absorption and immunological responses.
Function
Skin benefits
- Humectant
- Skin conditioning
Known concerns
- Very large protein (1466 aa) may have limited skin absorption
- Novel silkworm transgenic production
- Potential immunogenic concerns with large proteins
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related humectants
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.