Conditioning Agent
SOPHOCARPINE
Safety score · 0–100
Moderate
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A toxic quinolizidine alkaloid from Sophora plants — classified as 'Danger' for acute oral toxicity. Used in skin conditioning at very low doses.
Sophocarpine (CAS 6483-15-4) is a quinolizidine alkaloid found in Sophora flavescens (ku shen) and related legumes. GHS classification H301 (toxic if swallowed, 100%) with signal word 'Danger' indicates significant acute oral toxicity (LD50 likely < 300 mg/kg). While used in traditional Chinese medicine for anti-inflammatory effects, the acute toxicity classification limits its cosmetic application to very low concentrations. No EU restrictions listed, but the Danger signal word warrants careful dose management.
Function
Skin benefits
- Anti-inflammatory potential at safe concentrations
Known concerns
- Toxic if swallowed (H301) — Danger
- Alkaloid with significant systemic toxicity
- Narrow therapeutic/cosmetic window
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.