Conditioning Agent
RH-POLYPEPTIDE-62
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A 728-amino-acid recombinant Hepatocyte Growth Factor produced in E. coli, subject to EU restriction II/416, indicating SCCS-reviewed safety concerns requiring careful evaluation.
Rh-Polypeptide-62 is a recombinant human HGF produced by fermentation in E. coli. The restriction code 'II/416' in COSING indicates this ingredient has been reviewed under EU cosmetic regulation and carries specific safety restrictions or conditions (likely referencing SCCS opinion II/416). HGF is a potent growth factor with significant biological activity; the EU restriction suggests the SCCS identified concerns requiring restricted use or concentration limits in cosmetic products.
Function
Skin benefits
- Skin conditioning
- Skin protecting
Known concerns
- EU restriction II/416 applies - specific conditions required
- Potent growth factor with mitogenic activity
- SCCS review indicates safety concerns
- Requires compliance with specific use conditions
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.