Conditioning Agent
ORIDONIN
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A plant-derived compound from Rabdosia rubescens with anti-inflammatory properties — but flagged as a suspected carcinogen (H351). Used in traditional medicine, but raises safety red flags in skincare.
Oridonin (C₂₀H₂₈O₆, CAS 28957-04-2) is an ent-kaurane diterpenoid isolated from Rabdosia rubescens (Isodon rubescens). While it has demonstrated antineoplastic, antibacterial, anti-inflammatory, and apoptosis-inducing activities in research settings, it carries the GHS hazard code H351 (suspected of causing cancer). This carcinogenicity classification significantly limits its suitability for cosmetic use. It is listed in CosIng for skin conditioning but the H351 designation warrants serious caution. The paradox of an anticancer compound being a suspected carcinogen relates to its potent biological activity at different doses.
Function
Skin benefits
- Anti-inflammatory properties
- Antioxidant activity
- Traditional use in Chinese medicine for skin conditions
Known concerns
- H351 - Suspected of causing cancer
- Potent biological activity may cause unintended cellular effects
- Limited cosmetic safety data
- Not widely used in commercial skincare
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.