Conditioning Agent
SR-(OLIGOPEPTIDE-249 R-CLOSTRIDIUM BOTULINUM POLYPEPTIDE-1)
Safety score · 0–100
Caution
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A fusion peptide containing Clostridium botulinum sequences, raising the same significant safety concerns as other botulinum-derived ingredients despite recombinant production.
A recombinant fusion peptide produced in E. coli combining Oligopeptide-249 with r-Clostridium Botulinum Polypeptide-1. The Clostridium botulinum source association is highly concerning given the extreme toxicity of botulinum toxin; recombinant production removes the toxin but the genetic origin warrants caution under EU CMR and cosmetics guidelines. Subject to severe regulatory scrutiny. Very low product count indicates insufficient market safety data.
Function
Skin benefits
- Skin protection
- Skin conditioning
Known concerns
- Source organism: Clostridium botulinum
- Potential immunogenic response
- EU CMR substance scrutiny
- Extremely limited safety data
- Requires thorough toxicological justification
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related conditioning agents
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.