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SPHINGOSINE 1-PHOSPHATE

CAS 26993-30-6
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A phosphorylated bioactive lipid that regulates cell growth and migration but carries risk at elevated concentrations due to its pro-inflammatory signaling role.

Sphingosine 1-Phosphate (S1P) is a sphingolipid metabolite that acts as a potent signaling molecule regulating cell proliferation, migration, and immune cell trafficking. While naturally present in low concentrations in skin, elevated or exogenously applied S1P can trigger pro-inflammatory and angiogenic pathways. It is not specifically restricted under EU cosmetic regulations but its bioactive nature warrants caution; comprehensive safety data for topical cosmetic use remain limited.

Skin benefits

  • Regulates keratocyte proliferation and skin renewal
  • Supports sphingolipid-mediated barrier function signaling

Known concerns

  • Bioactive signaling molecule with potential pro-inflammatory effects at high concentrations
  • Limited long-term topical safety data
  • May affect immune cell trafficking and angiogenesis

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.