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Skin Conditioning

TETRAPEPTIDE-125

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic 4-amino-acid peptide used as a skin-conditioning agent at very low concentrations. Plausibly safe but with thin independent data.

Tetrapeptide-125 is a synthetic tetrapeptide (4 amino acids) supplied as a cosmetic actives concentrate, generally used at parts-per-million levels in skincare. Numbered INCI tetrapeptides are typically marketed for signaling-type benefits (e.g. firmness, smoothness) by individual ingredient houses. There is no CIR or SCCS opinion for this specific peptide and no GHS hazard classification. Short peptides of this size show minimal skin penetration intact and very low irritation potential at the levels used. Practical risk concerns are formulation-related rather than peptide-specific. Independent efficacy data is thin; supplier-generated studies dominate.

Function

SKIN CONDITIONING - MISCELLANEOUS

Skin benefits

  • Skin conditioning
  • Marketed firming/smoothing support
  • Low irritation potential

Known concerns

  • No independent regulatory review
  • Limited published evidence
  • Supplier-only efficacy data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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Check your shelf

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.