Skin Conditioning
TETRAPEPTIDE-42
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
About
A synthetic four-amino-acid peptide used as a skin-conditioning active. Low-risk by class; specific evidence is thin.
Tetrapeptide-42 is a defined-sequence synthetic four-amino-acid peptide used as a skin-conditioning agent. Tetrapeptides in cosmetic use have a generally clean safety profile — too large to deeply penetrate, broken down to amino acids by skin proteases, rarely sensitizing. No CIR or SCCS opinion exists. Independent peer-reviewed efficacy data is essentially absent; claims rely on supplier in vitro work.
Function
Skin benefits
- Skin conditioning
- Low irritation
- Defined synthetic sequence
Known concerns
- Limited independent data
- No regulatory review
- Supplier-driven claims
References
EU CosIng database
European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.