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Skin Conditioning

TETRAPEPTIDE-53

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic 4-amino-acid peptide for skin conditioning. Plausibly safe at trace levels; data is limited.

Tetrapeptide-53 is a synthetic 4-residue peptide supplied as a cosmetic skin-conditioning active at parts-per-million levels. Numbered INCI tetrapeptides are typically marketed for signaling-type benefits (firmness, smoothness) by specialty ingredient houses. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short peptides have negligible intact skin penetration and very low irritation potential at use levels. Independent efficacy and long-term safety data are thin; real-world risk is dominated by the surrounding formulation.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Marketed signaling support
  • Low irritation potential

Known concerns

  • No regulatory monograph
  • Sparse independent data
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.