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Skin Conditioning

TETRAPEPTIDE-58

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A synthetic four-amino-acid peptide used for skin conditioning. Likely safe by class, but specific data is limited.

Tetrapeptide-58 is a synthetic peptide of four amino acids used as a skin-conditioning agent in cosmetic formulations, typically at fractions of a percent. The numbered INCI indicates a defined supplier sequence, which may be proprietary. Short synthetic peptides as a class show favorable safety: low irritation, minimal sensitization, rapid enzymatic breakdown to amino acids on skin. No specific CIR or SCCS review exists for this peptide. Independent peer-reviewed efficacy data is sparse; claims rely on supplier in vitro and small-panel work. Considered low-risk, low-evidence.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Low irritation
  • Synthetic and defined

Known concerns

  • Limited independent data
  • No regulatory review
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.