Skin Conditioning
TETRAPEPTIDE-65
Safety score · 0–100
Fine
Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.
A short synthetic peptide (4 amino acids) used at very low percentages for skin conditioning. Likely safe but evidence is mostly supplier-generated.
Tetrapeptide-65 is a synthetic four-amino-acid peptide marketed for skin conditioning, typically used at fractions of a percent. As with most numbered cosmetic peptides, the exact sequence is supplier-controlled and not always public. Short synthetic peptides have a generally clean safety record — they are too large to penetrate deeply, biodegrade rapidly, and rarely cause sensitization. There is no specific CIR or SCCS review for this peptide. Independent peer-reviewed efficacy data is essentially absent; claims rely on in vitro studies from the supplier. Treated as low-risk, low-evidence.
Function
Skin benefits
- Low irritation potential
- Skin conditioning effects
- Synthetic, low contamination risk
Known concerns
- Sparse independent data
- Supplier-driven efficacy claims
- No regulatory dossier
References
EU CosIng database
European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.
Related skin conditionings
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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.