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TIOXOLONE

CAS 4991-65-5
52

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

Tioxolone is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Tioxolone (CAS 4991-65-5), also known as 6-hydroxy-2-oxo-1,3-benzoxathiolene, is a cyclic benzofuran derivative with established antibacterial and keratolytic activity used in topical dermatological products. It is listed in the EU CosIng database without specific restriction. The compound functions as a sulphone-type antibacterial agent but can cause skin dryness or irritation at higher concentrations. Safety data is limited compared to mainstream cosmetic ingredients, warranting a cautious approach in leave-on formulations.

Skin benefits

  • Antibacterial — effective against Cutibacterium acnes and Staphylococcus aureus
  • Keratolytic — promotes gentle dead skin cell shedding
  • Used in dermatological acne and psoriasis treatments

Known concerns

  • Skin irritation and drying potential at moderate-to-high concentrations
  • Limited long-term safety data in cosmetic contexts
  • Antibacterial agent — ecological concern for aquatic environments at high discharge

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.