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Skin Conditioning

TROLOXOYL NONAPEPTIDE-38

65

Safety score · 0–100

Fine

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A 9-amino-acid peptide capped with a Trolox (water-soluble vitamin E analog) group. Adds antioxidant character to a peptide; data is limited.

Troloxoyl Nonapeptide-38 is a synthetic nonapeptide modified at the N-terminus with a Trolox moiety. Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) is a water-soluble analog of alpha-tocopherol used in research as a reference radical scavenger; conjugating it to a peptide is intended to combine the antioxidant chromanol with peptide-style skin signaling at parts-per-million use levels. There is no CIR or SCCS opinion specific to this peptide and no published GHS classification. Short-to-medium peptides have negligible intact skin penetration and very low irritation potential at use levels. Independent efficacy and long-term safety data are thin; real-world risk is dominated by the surrounding formulation.

Function

SKIN CONDITIONING

Skin benefits

  • Skin conditioning
  • Antioxidant capacity from Trolox moiety
  • Low irritation at trace levels

Known concerns

  • No regulatory monograph
  • Sparse independent data
  • Supplier-driven claims

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.