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Urethane (Ethyl carbamate)

CAS 51-79-6
8

Safety score · 0–100

Avoid

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Urethane (ethyl Carbamate) is a cosmetic ingredient used in product formulations. Exercise caution due to limited available safety data.

Urethane, also known as ethyl carbamate (CAS 51-79-6), is a well-documented carcinogen and mutagen. It is classified by the IARC as Group 2A (probable human carcinogen) and by the EU SCCS as a substance of concern in cosmetics. EU Regulation 1223/2009 lists urethane/ethyl carbamate in Annex II (list of substances prohibited in cosmetic products), meaning it is banned from all cosmetic formulations in the EU. It has historically been found as an impurity in some fermented cosmetic products and alcoholic beverages. No safe concentration can be established for cosmetic use given its genotoxic carcinogenic mechanism. The extremely low score reflects its status as one of the most restricted cosmetic ingredients globally.

Skin benefits

  • None — no cosmetic benefit can justify use given risk profile

Known concerns

  • EU Annex II banned substance (prohibited in all cosmetic products)
  • IARC Group 2A probable human carcinogen
  • Genotoxic carcinogen
  • Mutagenic
  • No safe cosmetic use established

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.