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1-(beta-Aminoethyl)amino-4-(beta-hydroxyethyl)oxy-2-nitrobenzene and its salts

CAS 85765-48-6
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A nitro-substituted hair dye precursor with sensitisation potential, permitted at up to 1.0% concentration under EU Annex III rules.

This nitroaniline-derived hair dye intermediate is listed in EU Annex III of Cosmetics Regulation 1223/2009, with a maximum permitted concentration of 1.0% in the finished cosmetic product. The structural features — a nitro group and two amino/hydroxyethyl substituents — are associated with skin and respiratory sensitisation potential. Its chemistry is similar to other HC dyes that have documented contact dermatitis cases. Safe formulation use requires strict adherence to the 1.0% concentration ceiling and exclusion from products intended for eye use.

Known concerns

  • Skin and respiratory sensitisation potential
  • EU Annex III restricted — max concentration 1.0%
  • Nitro group contributes to reactive sensitising chemistry

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.