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2-METHOXYMETHYL-P-AMINOPHENOL HCL

CAS 135043-65-1
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

A methoxymethyl-substituted phenol derivative used in hair dyes, restricted in the EU under Annex III reference II/1216.

2-Methoxymethyl-p-aminophenol HCl is a phenol derivative hair dye intermediate restricted under EU Annex III/II/1216, meaning it is permitted only under specified conditions. This compound belongs to a subclass of aminophenol derivatives used in oxidative hair coloring. The EU SCCS has assessed methoxymethyl-substituted derivatives and set safe concentration limits, typically requiring batch testing for residual primary aromatic amine content. Its methoxy group modifies the typical phenol toxicity profile but过敏 sensitization potential remains.

Skin benefits

  • Used as a coupling intermediate in oxidative hair dye systems
  • Provides ash-brown to neutral tone development

Known concerns

  • EU Annex III restricted (II/1216) with specific concentration limits
  • Potential skin sensitization similar to other phenol derivatives
  • Residual primary aromatic amine content must be controlled
  • Requires careful batch testing for impurity profiling

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.