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1-Hydroxy-4-(p-toluidino)anthraquinone

CAS 81-48-1
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

Hydroxy-4-(p-toluidino)anthraquinone is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

1-Hydroxy-4-(p-toluidino)anthraquinone (CI 61205) is an anthraquinone-derived hair dye intermediate carrying GHS hazard warnings H317 (skin sensitization) and H413 (may cause long-lasting harmful effects to the aquatic environment). The EU CosIng database lists it under cosmetic regulations, and anthraquinone colorants are subject to specific purity requirements and concentration limits under Regulation 1223/2009. The para-toluidino substituent introduces additional toxicological considerations beyond the parent anthraquinone structure, with the SCCS noting structural alerts for certain toluidino-anthraquinone linkages.

Skin benefits

  • Delivers blue to violet tones in oxidative and semi-permanent hair dye formulations
  • Good lightfastness properties in hair coloring applications

Known concerns

  • Skin sensitization (H317)
  • Aquatic environmental hazard (H413)
  • EU SCCS has flagged anthraquinone colorants with toluidino substituents for careful assessment
  • Potential aromatic amine release raising genotoxicity concerns

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.