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3-(p-Chlorophenoxy)-propane-1,2-diol

CAS 104-29-0
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

About

P-Chlorophenoxy)-propane-1,2-diol is a cosmetic ingredient used in product formulations. Its specific function may vary between products. Exercise caution due to limited available safety data.

3-(p-Chlorophenoxy)-propane-1,2-diol (also called chlorophenesin or its phenoxy derivative) carries the GHS Danger signal word with H302 (harmful if swallowed), H315 (skin irritation), H318 (serious eye damage), H319 (serious eye irritation), H332 (harmful if inhaled), and H335 (respiratory irritation). This chlorinated phenoxy compound is used as a preservative and antimicrobial in some cosmetic formulations, though EU regulations have scrutinized chlorophenoxy preservatives for combined exposure concerns. It is distinct from the closely related preservative chlorophenesin (PCMX) but shares the chlorophenoxy functional group toxicology profile.

Skin benefits

  • Antimicrobial preservative properties
  • Broad-spectrum activity against bacteria and some fungi

Known concerns

  • Acute oral toxicity (H302)
  • Serious eye damage (H318)
  • Skin, eye, and respiratory irritation (H315/H319/H332/H335)
  • EU regulatory review of chlorophenoxy preservatives for cumulative exposure
  • Neurotoxicological concerns flagged in some REACH assessments for chlorophenoxy compounds

References

EU

EU CosIng database

European Commission cosmetic ingredient registry — regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve — always read the physical product label and consult a healthcare professional for personal concerns.