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4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone

CAS 81-14-1
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A nitrated ketone fragrance chemical (synthetic musk type) with moderate EU restrictions on maximum concentration across different product categories.

This dinitroacetophenone derivative is a synthetic nitromusk fragrance subject to EU Annex III restrictions with different limits by product type: 1.4% in fine fragrance, 0.56% in eau de toilette, and 0.042% in other products. The nitro group on an aromatic ring in combination with skin sensitization potential limits its acceptability, and cumulative exposure from multiple fragrance sources is a concern under ongoing SCCS review.

Known concerns

  • EU Annex III restricted — concentration limits by product category
  • Nitro-aromatic compound with sensitization potential
  • Cumulative nitromusk exposure under SCCS review

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.