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4,5-DIAMINO-1-((4-CHLOROPHENYL)METHYL)-1H-PYRAZOLE-SULFATE

CAS 163183-00-4
48

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A hair dye intermediate used for oxidative colouring, this pyrazole derivative is restricted in the EU to authorised oxidative hair dye formulations due to its potential to cause skin sensitisation.

This aromatic pyrazole sulfate functions as a primary intermediate in oxidative (permanent) hair dye systems. In the EU it is listed in Annex III (the positive list of substances restricted in cosmetic products), specifically entry 1218, with maximum concentration limits applied at the point of mixing for oxidative hair dye use. It carries a known risk of contact sensitisation and requires caution in handling.

Known concerns

  • Skin sensitisation potential
  • EU Annex III restricted — authorised use only in oxidative hair dye formulations
  • Requires cautionary labelling and patch testing guidance

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.