4,6-BIS(2-HYDROXYETHOXY)-M-PHENYLENEDIAMINE
Other
Avoid
About 4,6-BIS(2-HYDROXYETHOXY)-M-PHENYLENEDIAMINE
A hydroxyethoxy-substituted aromatic diamine hair dye intermediate restricted under EU Regulation II/1307, with mutagenicity concerns from the nitro-group-like structure.
Detailed Analysis
4,6-Bis(2-hydroxyethoxy)-m-phenylenediamine is an aromatic diamine with two hydroxyethoxy substituents, regulated under EU Regulation 1223/2009 Annex II entry 1307. The hydroxyethoxy groups increase water solubility but also the potential for skin penetration. Like other aromatic diamine hair dye intermediates, it carries concerns for skin sensitization and potential mutagenic activity. The compound is restricted to professional hair dye use only, with maximum concentration limits in the finished product. The multiple hydroxyl and ether functionalities create a highly polar molecule that may have different absorption characteristics than simpler aromatic amines. The 2-hydroxyethoxy substituents are structurally analogous toethylene glycol ethers, some of which have toxicity concerns.
Skin Benefits
- ✓ Hair dye intermediate for specialized color formulations in professional settings
Known Concerns
- ⚠ EU Annex II/1307 restricted hair dye intermediate
- ⚠ Skin sensitization potential
- ⚠ Mutagenicity concerns
- ⚠ Professional use only — concentration limits apply
Safety Score
Avoid
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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