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4-DIHYDROMETHYL-2H-PYRAN-2-YL GUAIACOL

CAS 128489-02-1
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A guaiacol derivative with a dihydropyran ring, used primarily as a fragrance or flavor material. Carries H317 (skin sensitizer) and H412 (hazardous to aquatic life) hazard statements, requiring caution in cosmetic formulation.

This compound is a cyclic ether-phenol (guaiacol connected via a dihydropyran ring) that contributes to fragrance compositions. It is classified under GHS as H317 (may cause an allergic skin reaction) and H412 (harmful to aquatic life with long-lasting effects). EU Annex III may require restrictions for such sensitizing fragrance materials per the IFRA Standards. Not extensively studied for chronic dermal exposure.

Skin benefits

  • Used as fragrance component
  • Antioxidant properties of guaiacol moiety

Known concerns

  • H317 — skin sensitizer (delayed hypersensitivity)
  • H412 — toxic to aquatic organisms, long-lasting effects
  • Fragrance allergen — may require declaration in EU IFRA context
  • Limited chronic toxicological data

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.