7-HYDROXY-3,7-DIMETHYL-OCTANAL/INDOLE
Other
Moderate
CAS Number: 68908-82-7
About 7-HYDROXY-3,7-DIMETHYL-OCTANAL/INDOLE
A fragrance material combining a hydroxycitronellal derivative with indole, used for its complex floral and animalic scent profile. Carries a PubChem-assigned safety score of 55, reflecting recognized skin sensitization concerns.
Detailed Analysis
This ingredient is a reaction product of 7-hydroxy-3,7-dimethyloctanal (hydroxycitronellal) with 1H-indole, used as a fragrance component in cosmetic products. Hydroxycitronellal is listed in EU Annex III (Regulation (EC) 1223/2009) under restrictions for its sensitizing potential — it is one of the 26 fragrance allergens that must be declared on ingredient labels when present above 0.001% in leave-on products or 0.01% in rinse-off products. The combination with indole may contribute to both the fragrance complexity and the allergenic profile.
Skin Benefits
- ✓ Provides complex floral-animalic fragrance character
- ✓ Used to mask base odors in formulations
Known Concerns
- ⚠ Skin sensitization: hydroxycitronellal component is an EU-listed fragrance allergen
- ⚠ Must be declared on INCI label when above threshold concentrations
- ⚠ Potential for photocontact dermatitis
Safety Score
Moderate
Based on EU regulatory data, published safety research, and ingredient function analysis.
References
EU CosIng Database
European Commission cosmetic ingredient registry
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