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7-HYDROXY-3,7-DIMETHYL-OCTANAL/INDOLE

CAS 68908-82-7
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A fragrance material combining a hydroxycitronellal derivative with indole, used for its complex floral and animalic scent profile. Carries a PubChem-assigned safety score of 55, reflecting recognized skin sensitization concerns.

This ingredient is a reaction product of 7-hydroxy-3,7-dimethyloctanal (hydroxycitronellal) with 1H-indole, used as a fragrance component in cosmetic products. Hydroxycitronellal is listed in EU Annex III (Regulation (EC) 1223/2009) under restrictions for its sensitizing potential — it is one of the 26 fragrance allergens that must be declared on ingredient labels when present above 0.001% in leave-on products or 0.01% in rinse-off products. The combination with indole may contribute to both the fragrance complexity and the allergenic profile.

Skin benefits

  • Provides complex floral-animalic fragrance character
  • Used to mask base odors in formulations

Known concerns

  • Skin sensitization: hydroxycitronellal component is an EU-listed fragrance allergen
  • Must be declared on INCI label when above threshold concentrations
  • Potential for photocontact dermatitis

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.