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ALPHA-DAMASCONE

CAS 23726-94-5 / 43052-87-5
55

Safety score · 0–100

Moderate

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A fruity-floral fragrance ingredient — smells like roses and plums but is a known skin sensitiser. EU-restricted with strict concentration limits in products.

Alpha-Damascone (CAS 23726-94-5, PubChem CID 520506) is a ketone fragrance compound with a powerful fruity-floral rose/plum odour profile, listed under EU Annex III/157. The SCCS identified it as a significant skin sensitiser with a low NESIL (No Expected Sensitisation Induction Level). EU regulation imposes strict concentration limits: 0.02% in leave-on products and 0.1% in rinse-off products. It is structurally related to beta-damascone and damascenone, all derived from ionone chemistry. IFRA (International Fragrance Association) also restricts its use in fragrance compositions.

Known concerns

  • Known skin sensitiser — EU Annex III restricted
  • Strict concentration limits (0.02% leave-on, 0.1% rinse-off)
  • Cross-sensitisation with other damascones possible
  • Must be labelled when above threshold in products

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.