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Benzyl 4-hydroxybenzoate (INCI: Benzylparaben)

CAS 94-18-8
35

Safety score · 0–100

Caution

Derived from EU CosIng regulatory status, PubChem hazard data and published research. How we score.

A paraben ester used as a preservative with documented concerns about endocrine-disruption potential, leading to significant EU regulatory scrutiny.

Benzylparaben (CAS 94-18-8) is the benzyl ester of 4-hydroxybenzoic acid (parabens family), used as an antimicrobial preservative in cosmetic and pharmaceutical formulations. Parabens as a class have been subject to extensive EU regulatory review. While methylparaben and ethylparaben are listed in Annex V (allowed preservatives) with specific concentration limits, the benzyl ester sits in a more uncertain regulatory space. The SCCS has expressed concern about the endocrine-disruption potential of longer-chain parabens and benzylparaben specifically. SCCS opinions have noted that benzylparaben shows endocrine activity in vitro, which has led to its de facto non-use in EU cosmetics despite not being formally listed in Annex II.

Skin benefits

  • Antimicrobial preservation extending product shelf life

Known concerns

  • Suspected endocrine disruption activity per SCCS scientific opinions
  • H315/H319/H335 - irritant to skin, eyes, and respiratory tract
  • Regulatory uncertainty in EU due to parabens scrutiny
  • Not listed in EU permitted preservative annexes creating compliance ambiguity

References

EU

EU CosIng database

European Commission cosmetic ingredient registry: regulatory status, restrictions, authorised functions.

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This profile is for educational purposes and does not constitute medical advice. Regulatory status and scientific understanding evolve, so always read the physical product label and consult a healthcare professional for personal concerns.